|
KMID : 0960920020010010053
|
|
Dementia and Neurocognitive Disorders
2002 Volume.1 No. 1 p.53 ~ p.56
|
|
|
Cimetidine Treatment of Hypersexuality Associated with Stoke
|
|
Yu Kyung-Ho
Ma Hyeo-Il
Jeong Seung-Cheol
Lee Byung-Chul
|
|
|
Abstract
|
|
|
Most studies have agreed that there is a considerable decline in sexual activity following stoke, but the hypersexuality after stoke as a relatively isolated behavioral abnormality has been less frequently reported. Hypersexuality has no proven
treatment, although repeorts have described reductions in hypersexual behavior using anti-androgens, anti-psychotics of serotonergics. However, patients, whose sexual behavior did not response to these medications, were not uncommonly observed in clinical practice. A 65-year-old right-handed male presented with acute left hemiparesis. His MRI showed a right middle cerebral artery infract invloving the temporal, parietal regions and the basal ganglia. Four weeks after stoke, he showed abnormal behavior, such as incessantly holding and hugging the nursing staff without assent, but no increased orality of change in eating habits. But several weeks after taking cimetidine, a histamine H2-receptor antagonist, his sexual behavior showed a marked improvement. This case demonstrates that cimetidine as a non-homonal anti-androgenic effect decreased libido and hypersexual behavior without serious side effects in patients with cognitive decline after stroke. Further studies that obviously define the response and long-term side effects of cimetidine are need to confirm our observations.
|
|
|
KEYWORD
|
|
|
Sexual Dysfunctions, Cognitive Disorders, Cimetidine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|
|